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ZENTAMINE (Darbepoetin Alfa) is an erythropoiesis-stimulating agent produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. The final processed form is a 165-amino acid protein containing 5 N-linked oligosaccharide chains and 1 O-linked oligosaccharide chain. Darbepoetin Alfa injection causes the bone marrow to produce red blood cells in patients with severe anemia. Darbepoetin may be used for patients on kidney dialysis or for those not on dialysis.
ERYNEX is recombinant human erythropoietin alpha (rHuEPO). Erythropoietin is a glycoprotein, which stimulates red blood cell (Erythropoiesis) production. It is produced in the kidney and stimulates the division and differentiation of committed erythroid progenitors in the bone marrow. Erythropoietin stimulates erythropoiesis in anemic patients with chronic renal failure in whom the endogenous production of erythropoietin is impaired.
